Biomarkers for Monitoring Treatment Response of Omalizumab in Patients with Chronic Urticaria
نویسندگان
چکیده
Chronic urticaria (CU) is a debilitating skin disease affecting around 1% of the population. CU can be subdivided into chronic spontaneous (CSU) and inducible (CIndU). Different pathophysiological mechanisms have been proposed to play role in development CU, these are also being investigated as potential biomarkers diagnosis management disease. As now only assessment tools available for treatment response patient reported outcomes (PROs). Although both validated widely used, they leave desire more objective measurements. A biomarker broad subcategory observations that used an accurate, reproducible, indicator clinically relevant outcomes. This could normal biological or pathogenic processes, intervention exposure, e.g., response. Herein we provide overview with focus on prognostic omalizumab, thereby potentially aiding physicians personalizing treatments.
منابع مشابه
Effects of Omalizumab Treatment in Patients With Refractory Chronic Urticaria
PURPOSE Chronic urticaria (CU) is a common and debilitating disease, and the need for effective treatment has increased. Omalizumab may be an alternative regimen in patients with CU who do not respond to conventional treatments. The aim of this study is to investigate the efficacy and to observe the clinical results of omlizumab in patients with refractory CU. METHODS We conducted a retrospec...
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Chronic idiopathic urticaria (CIU) is a common autoimmune skin condition characterized by spontaneously recurring hives for 6 weeks or longer. The new terminology used for CIU in most countries including Canada is chronic spontaneous urticaria (CSU). CSU is associated with significant psychosocial morbidity with a markedly negative impact on overall quality of life. Conventional approaches with...
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چکیده ندارد.
15 صفحه اولOmalizumab for the treatment of chronic idiopathic or spontaneous urticaria.
BACKGROUND Many patients with chronic idiopathic urticaria (also called chronic spontaneous urticaria) do not have a response to therapy with H-antihistamines, even at high doses. In phase 2 trials, omalizumab, an anti-IgE monoclonal antibody [corrected] that targets IgE and affects mast-cell and basophil function, has shown efficacy in such patients. METHODS In this phase 3, multicenter, ran...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2023
ISSN: ['1661-6596', '1422-0067']
DOI: https://doi.org/10.3390/ijms241411328